Open MathewGolding opened 7 months ago
@MathewGolding is the action not rather testing Excel/bar code scanner for tracking compound/logistics?
I will add that on there now.
15/01/24
2A - Should be receiving compounds soonish - Suzuki first -> reductive aminations, williamson ethers, amidations, etc. then Buchwald Hartwig.Prepare
25/01/24
29/01/24
[x] Review talk outline in powerpoint for presentation, figures, etc
[ ] Do paladium catalyst - solvent tests n.b. get Tom Webb's data (message today (12/02/24)) Don't have enough catalyst to reasonably do this for suzuki. Keep in mind for Buchwal-Hartwig. -> Research literature for the solubility of these catalysts.
[x] Redo LCMS of starting materials in one LCMS plate well (create mixture) - compare rrf value of at least one
[x] Do test reactions on small scale suzuki test reactions to get used to them -> start with suz-2 4x4 combichem (analysis can also be done to do lcms for mscheck analysis)
[x] Create a cheminv catalogue ticket -> better organise the many tasks chem inventory needs doing (move old assignments to new - create physical and data names for the cabinets)
[x] Get label maker working for the physical labels
[x] Fill out waste disposal forms and clear out waste cabinet
[x] Organise the "trolley" - select whether keep/disgard items
[x] Dry and then wet run of 96 reactant vials
[x] Update LCMS and CAR SOPs
[ ] Create confluence page for ChemInv and other documentation
[ ] Create project to do lists to separate project goals and view them more succinctly:
- [x] Create project tickets
- [ ] Populate the tickets
[ ] Check pubchem api methods for Cas number -> smiles searching
[x] Order 96 well filtration plates - need quote from Biotage -> hasn't replied yet
[x] Review talk outline in powerpoint for presentation, figures, etc
[ ] Do paladium catalyst - solvent tests n.b. get Tom Webb's data (message today (12/02/24)) Don't have enough catalyst to reasonably do this for suzuki. Keep in mind for Buchwal-Hartwig. -> Research literature for the solubility of these catalysts.
[x] Review Tomm's uploads to CAR (@Waztom to share) for Suz-2 reactions
[ ] Add a multi-suzuki recipe to CAR and test upload/script creation
[x] Waste cabinet organisation - NOTE: get caps for waste bottles
[ ] Organise the "trolley" - NOTE: select whether keep/disgard items - go through after meeting
[x] Update LCMS and CAR SOPs - NOTE: Update encoded recipe used
[ ] Create confluence page for ChemInv and other documentation - @Waztom to create first fast forward fragments confluence page
[x] LCMS of all start materials again
[x] Measure accuracy and precision of OT 10 uL transfers (0.5-5 uL scale) and then 300 uL (20-200 uL scale)
[x] Create project to do lists to separate project goals and view them more succinctly:
- [x] Create project tickets
- [x] Populate the tickets
[ ] Check pubchem api methods for Cas number -> smiles searching
[x] Set up MestReNova
[x] T-Server into the DIAMRD4323 machine
[x] Prepare 0.1 mM standard and run LCMS for wasgo iter 1.1 batch 1 (high priority - today)
[ ] analyse batch 1 via MSCheck and manual review to gain conversion estimates
[ ] Get press to lab - speak to Mic (beamline engineer) - tbd next week?
[ ] Plan a suitable set of reaction that would prove the effectiveness of "print-press" reactions in a HTE format - ticket - tbd next week?
[ ] Wasgo iter-2 - review compounds ordered and plan chemistry to execute on CAR for iter-2 compounds - tbd next week?
[ ] Begin fridge/freezer clean up?
[x] Review CAR 384 plates 100 uL labcyte echo set up
[x] Prepare 0.1 mM standard and run LCMS for wasgo iter 1.1 batch 1 (high priority - today)
[ ] analyse batch 1 via MSCheck and manual review to gain conversion estimates
[ ] Get press to lab - speak to Mic (beamline engineer) - tbd next week?
[ ] Plan a suitable set of reaction that would prove the effectiveness of "print-press" reactions in a HTE format - ticket - tbd next week?
[ ] Wasgo iter-2 - review compounds ordered and plan chemistry to execute on CAR for iter-2 compounds - tbd next week?
[ ] Begin fridge/freezer clean up?
[ ] analyse iter 1.0 and iter 1.1 batch 2 via MSCheck excel template to gain conversion estimates (~100)
[ ] Get Lab PC and network this PC to diamond (@Waztom)
[ ] Get press to lab - speak to Mic (beamline engineer) - tbd next week?
[ ] Plan a suitable set of reaction that would prove the effectiveness of "print-press" reactions in a HTE format - ticket - tbd next week?
[ ] Wasgo iter-2 - review compounds ordered and plan chemistry to execute on CAR for iter-2 compounds - tbd next week?
[ ] Begin fridge/freezer clean up
[ ] Begin Lab clean up -> see action list in emails from Warren
08/01/24