Weeks-UNC / shapemapper2

Public repository for ShapeMapper 2 releases
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problem with sequence corrector #37

Closed irinatu closed 10 months ago

irinatu commented 1 year ago

I have Error message that I do not understand completely. Could you help me, please?

Running SequenceCorrector at 2022-11-03 11:25:43 . . .

ERROR: Component "SequenceCorrector" failed, giving the following error message:============================================================== Traceback (most recent call last): File "/home/irina/bin/shapemapper-2.1.5/internals/python/pyshapemap/../../bin/make_variant.py", line 430, in merged_variants) File "/home/irina/bin/shapemapper-2.1.5/internals/python/pyshapemap/../../bin/make_variant.py", line 325, in correct_sequence raise RuntimeError(s) RuntimeError: Error: Unable to determine variant sequence. Conflicting (overlapping) variant sequences present.

Psirving commented 1 year ago

I'm not entirely certain, but I think this means that SequenceCorrector is detecting multiple variants and that they are too different to merge into a single "correct" sequence. For example, if there were two alleles that are multiple SNPs away from the provided fasta in different directions, it might produce this error.

irinatu commented 1 year ago

Thank you for a prompt reply. Best regards, Irina.

From: Patrick Irving @.> Date: Thursday, 3 November 2022 at 17:15 To: Weeks-UNC/shapemapper2 @.> Cc: irinatu @.>, Author @.> Subject: Re: [Weeks-UNC/shapemapper2] problem with sequence corrector (Issue #37)

I'm not entirely certain, but I think this means that SequenceCorrector is detecting multiple variants and that they are too different to merge into a single "correct" sequence. For example, if there were two alleles that are multiple SNPs away from the provided fasta in different directions, it might produce this error.

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