If you can't disable WD, can you try to add an exception to the SA2 folder?
If you can't, you can try to set the update channel to developpement in the Manager Config tab and see if the last build fix it? (Download the last version here if you don't have the option)
Keep in mind that overall, we don't have control on false positive.
Windows defender block SA2 Launch , flagged as Wacatac!Bml (critical)
Screenshots
Desktop (please complete the following information):
Additional context I play on a cloud gaming service, WD can't be disabled