Question about "Amino acid conservation at each position is determined"

XieResearchGroup / DISAE

MSA-Regularized Protein Sequence Transformer toward Predicting Genome-Wide Chemical-Protein Interactions: Application to GPCRome Deorphanization

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Question about "Amino acid conservation at each position is determined" #9

Open Shuqi-li opened 2 years ago

Shuqi-li commented 2 years ago

Hi, I am confused about the sentence "Amino acid conservation at each position is determined" in your paper. How could you get conservation score of each position? we could download them from database or we have to calculate in some way?

Could you please describe the process in as much detail as possible? Thank you very much!!!