Validate HM450K QC data with WGBS data to better define the reference for QC fluorescence intensity

YoannPa / methview.qc

HM450.QCView allows you to generate quality control plots from your Human Methylation 450K dataset.

GNU General Public License v3.0

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Validate HM450K QC data with WGBS data to better define the reference for QC fluorescence intensity #11

Closed YoannPa closed 1 year ago

YoannPa commented 3 years ago

Is your feature request related to a problem? Please describe. Currently the reference for QC fluorescence is based on the average fluorescence among PCAWG HM450K samples. It would be better to select HM450K samples based on matching WGBS data: to keep HM450K for which the methylation profiles match the WGBS methylation profile.

Describe the solution you'd like Validate HM450K with matching WGBS.