YosefLab / Cassiopeia

A Package for Cas9-Enabled Single Cell Lineage Tracing Tree Reconstruction
https://cassiopeia-lineage.readthedocs.io/en/latest/
MIT License
75 stars 24 forks source link

Computing tree likelihoods #231

Open Marius1311 opened 10 months ago

Marius1311 commented 10 months ago

Hi Cassiopeia team, I was wondering whether there would be a place in the documentation where I can find more information about the computation of tree likelihoods in Cassiopeia? For example, whether to use the continuous or the discrete model. Is that described in any of your publications?

Basically, I would like to evaluate how good my reconstructed lineage trees are, and I thought this could be a good way to do so. I just tried naively, but both functions give me ParameterEstimateError: Neitherheritable_missing_ratenorstochastic_missing_probabilitywere provided as arguments or found intree.parameters. Please provide one of these parameters, otherwise they are convolved and cannot be estimated

I'm not sure how I should estimate either of these parameters for my data. Any help would be appreciated. thanks in advance!