update KEGG api

[huerqiang]

Fix https://github.com/YuLab-SMU/clusterProfiler/issues/551 KEGG api修改后， createKEGGdb也需要做响应的修改。

> 
> data(geneList, package="DOSE")
> gene <- names(geneList)[abs(geneList) > 2]
> kk <- enrichKEGG(gene = gene,
+ organism = 'hsa',
+ pvalueCutoff = 0.05,
+ qvalueCutoff = 0.05,
+ use_internal_data =T)
> nrow(kk)
[1] 9
> head(kk)
               ID                                                   Description GeneRatio  BgRatio       pvalue     p.adjust       qvalue                                             geneID Count
hsa04110 hsa04110                                                    Cell cycle     11/94 127/8275 1.689644e-07 3.531357e-05 3.450432e-05 8318/991/9133/890/983/4085/7272/1111/891/4174/9232    11
hsa04114 hsa04114                                                Oocyte meiosis     10/94 131/8275 2.051606e-06 2.143928e-04 2.094797e-04    991/9133/983/4085/51806/6790/891/9232/3708/5241    10
hsa04218 hsa04218                                           Cellular senescence     10/94 156/8275 9.875269e-06 6.879771e-04 6.722113e-04     2305/4605/9133/890/983/51806/1111/891/776/3708    10
hsa04061 hsa04061 Viral protein interaction with cytokine and cytokine receptor      8/94 100/8275 1.622516e-05 8.477647e-04 8.283372e-04           3627/10563/6373/4283/6362/6355/9547/1524     8
hsa03320 hsa03320                                        PPAR signaling pathway      7/94  75/8275 2.061911e-05 8.618789e-04 8.421279e-04                 4312/9415/9370/5105/2167/3158/5346     7
hsa04914 hsa04914                       Progesterone-mediated oocyte maturation      7/94 102/8275 1.496049e-04 5.211236e-03 5.091815e-03                    9133/890/983/4085/6790/891/5241     7

[dulunar]

你好，请问是不是只更新了clusterProfiler4的代码，3的会不会跟进更新，谢谢，因为机器上的r没有更新到4.2，故发此问。

[huerqiang]

是的，必须安装Github上最新的版本才可以。