Mural Cell

[cerivs]

From Sabrina:

I think that the following should be correct:

Vasculature has_part endothelial cell Vasculature has_part mural cell vascular smooth muscle cells is_a mural cell pericyte is_a mural cell

New term : mural cell (MC) Parent: vasculature Children:

• vascular smooth muscle cells (VSMC)
• pericyte

Reference:

• ZDB-PUB-160310-12
• Gaengel, K., Genove, G., Armulik, A. and Betsholtz, C. (2009). Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler. Thromb.Vasc. Biol. 29, 630-638

Ontology (based on above references): vasculature

• endothelial cells (inner surface of the blood vessels)
• mural cells (cover the abluminal surface of the endothelial cell -- vascular smooth muscle cells (VSMCs) : multi-layered cells, ensheath ECs -- pericytes : solitary cells associated with small diameter blood vessels such as arterioles, venules and capillaries

[cerivs]

This will probably require some improvements to blood vessel structure Blood vessel

tunica externa blood vessel= tunica adventitia, adventitia: Outter layer of blood vessel composed of fibroblasts, connective tissue, and perivascular nerves. Also a site of immune surveillance and a stem cell niche. PMID:21677296

tunica media blood vessel

tunica lamina arerteries: an elastic layer that supports the tunica externa.

Tunica externa = tunica adventitia = adventitial layer : The membranous covering of an organ or the outter layer of the wall of a hollow structure,

PMID: 16212810 Pericytes were described more than 100 years ago as perivascular cells that wrap around blood capillaries (peri, around; cyte, cell). They are also called Rouget cells after their discoverer, Charles Rouget, or referred to as mural cells or, because of their contractile fibers, as vascular smooth muscle cells (vSMCs)

In general, pericytes possess a cell body with a prominent nucleus and a small content of cytoplasm with several long processes embracing the abluminal endothelium wall (Figs. 1A.a and b). They are embedded within the basement membrane of microvessels, which is formed by pericytes and endothelial cell

ZDB-PUB-160310-12 https://zfin.org/ZDB-PUB-160310-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871727/ http://neuro-oncology.oxfordjournals.org/content/7/4/452 http://atvb.ahajournals.org/content/29/5/630.full http://atvb.ahajournals.org/content/31/7/1530.full http://atvb.ahajournals.org/content/31/7/1530.full http://www.ncbi.nlm.nih.gov/pubmed?holding=&cmd=search&term=The%20Adventitia%20Guenter%20Daum http://discovery.lifemapsc.com/in-vivo-development/lateral-plate-mesoderm/splanchnic-mesoderm/mural-cells

[sabrinatoro]

other publication with mural cells: ZDB-PUB-170126-1

[cerivs]

In Zebrafish literature "mural cell" is usually used to refer to pericytes, it may also refer to mesenchymal cells or vascular smooth muscle cells. Since it isn't a specific cell type we won't be making a term for this in the ZFA. Fish Physiology Volume 29 "Zebrafish" Jon D. Malby and Sarah J. Childs page 249-287.

[sabrinatoro]

@cerivs : I have papers in which the authors created Tg line to study mural cells (vascular smooth muscle cells and pericytes) specifically and they looked at their origin and their role during vasculature development. Using the terms "smooth muscle cells" or "pericytes" would not be correct since the authors couldn't make the distinction between these cells. Also, I cannot post-compose "cells surrounding the endothelial cells" since we do not have a spatial term to express the fact that these cells are cells which are separate from a structure and surround it. Could you please advice which term(s) or post-composition would be the correct one to use, please? Thank you.

[sabrinatoro]

from discussion: Use vascular smooth muscle cell

[cerivs]

More papers have been published review ticket ZDB-PUB-190116-4 and ZDB-PUB-200520-6