2022-08-15T09:18:25 sra-stat.2.8.0 sys: connection failed while opening file within cryptographic module - mbedtls_ssl_handshake returned -9984 ( X509 - Certificate verification failed, e.g. CRL, CA or signature check failed )
2022-08-15T09:18:25 sra-stat.2.8.0 sys: mbedtls_ssl_get_verify_result returned 0x8 ( !! The certificate is not correctly signed by the trusted CA )
2022-08-15T09:18:25 sra-stat.2.8.0 sys: connection failed while opening file within cryptographic module - mbedtls_ssl_handshake returned -9984 ( X509 - Certificate verification failed, e.g. CRL, CA or signature check failed )
2022-08-15T09:18:25 sra-stat.2.8.0 sys: mbedtls_ssl_get_verify_result returned 0x8 ( !! The certificate is not correctly signed by the trusted CA )
2022-08-15T09:18:25 sra-stat.2.8.0 int: directory not found while opening manager within virtual file system module - 'SRR7062961'
2022-08-15T09:18:25 sra-stat.2.8.0 sys: connection failed while opening file within cryptographic module - mbedtls_ssl_handshake returned -9984 ( X509 - Certificate verification failed, e.g. CRL, CA or signature check failed ) 2022-08-15T09:18:25 sra-stat.2.8.0 sys: mbedtls_ssl_get_verify_result returned 0x8 ( !! The certificate is not correctly signed by the trusted CA ) 2022-08-15T09:18:25 sra-stat.2.8.0 sys: connection failed while opening file within cryptographic module - mbedtls_ssl_handshake returned -9984 ( X509 - Certificate verification failed, e.g. CRL, CA or signature check failed ) 2022-08-15T09:18:25 sra-stat.2.8.0 sys: mbedtls_ssl_get_verify_result returned 0x8 ( !! The certificate is not correctly signed by the trusted CA ) 2022-08-15T09:18:25 sra-stat.2.8.0 int: directory not found while opening manager within virtual file system module - 'SRR7062961'
solution: Download the latest sra-toolkit from https://github.com/ncbi/sra-tools/wiki/01.-Downloading-SRA-Toolkit tar -xvf {zip files} cd bin ./vdb-config --interactive Then fastq-dump and parallel-fastq-dump should work