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aarsonline / aarsonline.github.io

AARS Online - an interactive database of aminoacyl-tRNA synthetase sequences, structures, and taxonomy
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LysRS-I discussion. Please use this tag #31

Open jordandouglas opened 10 months ago

MikeIbba commented 9 months ago

Edits:

  1. Change "by catalyzing the attachment of the amino acid arginine to its cognate tRNA" to "by catalyzing the attachment of the amino acid lysine to its cognate tRNA".
  2. It is worth adding text to state that LysRS-I is in a subclass of class I aaRSs that require the presence of tRNA for aa-AMP synthesis.
MikeIbba commented 9 months ago

Also, a few organisms encode both LysRS-I and LysRS-2

jordandouglas commented 9 months ago

Very important to get the name of the substrate right!

Mike, do you know much about that beta rich loop on the surface of the catalytic domain called "LysRS IM"? It is unique to this enzyme but I don't know if it has been functionally characterised. I would speculate it is involved in tRNA recognition