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aarsonline / aarsonline.github.io

AARS Online - an interactive database of aminoacyl-tRNA synthetase sequences, structures, and taxonomy
GNU General Public License v3.0
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ArgRS discussion. Please use this tag #9

Open jordandouglas opened 1 year ago

mariesissler commented 10 months ago

Jordan, I have noticed in the description of ArgRS the sentence "While most Class I aminoacyl-tRNA synthetases are monomeric, ArgRS is homodimeric. " Do you have a reference for that? According to me ArgRSs are monomers (but suddenly, reading this I have a doubt) Marie

jordandouglas commented 10 months ago

Hi Marie, I think you are right. My reference was Table 1 of the review paper @MikeIbba

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373986/

But I cannot find any primary evidence that ArgRS is a dimer under normal conditions (only as part of the SerRS-ArgRS complex in Archaea, or as an inactive state upon hemin binding). I will update the page to reflect this

MikeIbba commented 10 months ago

Apologies, that table is a mess, I missed that in the proofreading when they re-made the table. ArgRS should be a monomer, TyrRS a dimer… yikes!