abyzovlab / CNVnator

a tool for CNV discovery and genotyping from depth-of-coverage by mapped reads
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CNVnator e-val2 #156

Closed hzjsxu closed 3 years ago

hzjsxu commented 5 years ago

Dear professor Alexej Abyzov, Hello, in my results I could get really large e-vals (>>1) as follows. I have difficulty understanding what each one of the four e-vals indicates..... do you by any chance have idea what are they trying to test for each of the e-vals? And the e-val2 which >>1 is wrong or how to solve it? cnv_output

Thanks in advance for your reply. jsxu

abyzov commented 5 years ago

Hi, there are two ways to calculate e-vals. If either e-val1 or e-val2 pass significance CNVnator reports such a call.

Alexej Abyzov, Ph.D. Senior Associate Consultant, Assistant Professor of Biomedical Informatics, Department of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic

Mayo Clinic, 200 1st street SW, Harwick 3-12 Rochester, MN 55905 www.abyzovlab.orghttp://www.abyzovlab.org tel: +1-(507)-538-0978 fax: +1-(507)-284-0745

hzjsxu commented 5 years ago

Hi, there are two ways to calculate e-vals. If either e-val1 or e-val2 pass significance CNVnator reports such a call. Alexej Abyzov, Ph.D. Senior Associate Consultant, Assistant Professor of Biomedical Informatics, Department of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic ----------------------------- Mayo Clinic, 200 1st street SW, Harwick 3-12 Rochester, MN 55905 www.abyzovlab.org<http://www.abyzovlab.org> tel: +1-(507)-538-0978 fax: +1-(507)-284-0745

ok thanks. that's to say, if one of e-val1 or e-val2 passes the significance, then I can consider it reasaonable. Right?

abyzov commented 5 years ago

Yes.

Alexej Abyzov, Ph.D. Senior Associate Consultant, Assistant Professor of Biomedical Informatics, Department of Health Sciences Research, Center for Individualized Medicine, Mayo Clinic

Mayo Clinic, 200 1st street SW, Harwick 3-12 Rochester, MN 55905 www.abyzovlab.orghttp://www.abyzovlab.org tel: +1-(507)-538-0978 fax: +1-(507)-284-0745