English - same voice used no matter which region is selected
Nederlands - nl-NL and nl-BE - no real effect in VoiceOver, pronounced identically in NVDA, pronounced as English in JAWS
Português - pt-PT and pt-BR - pronounced differently in VoiceOver, pronounced same in JAWS/NVDA
Cantonese - zh-HK pronounced as Cantonese in VoiceOver, Mandarin in NVDA, not read in JAWS
Mandarin - zh-HK pronounced as Mandarin in VoiceOver, Mandarin in NVDA, not read in JAWS
In addition to Cantonese/Mandarin there may be similar issues with pt-PT and pt-BR. European Portuguese speakers find Brazilian Portuguese easy, but some Brazilian Portuguese speakers find European Portuguese hard to understand:
https://youtu.be/wfs_PNA_R-M?t=95
Here's test data on non-primary language region subtags https://qa.powermapper.com/Tests/ACT-R/primary-ext-lang.html
In addition to Cantonese/Mandarin there may be similar issues with pt-PT and pt-BR. European Portuguese speakers find Brazilian Portuguese easy, but some Brazilian Portuguese speakers find European Portuguese hard to understand: https://youtu.be/wfs_PNA_R-M?t=95