SAL review

[adamjtaylor]

PR opened to address comment's by Caterina Minelli as NPL Science Area Leader reviewer

Abstract

• [x] Add department to all affiliations
• [x] In Abstract: These two techniques are highly complementary, offering greater sensitivity to...greater than what Response: respective to one another

• [x] LDA use acronym at end of abstract as already introduced

  Intro

• [x] Intro line 1 Inconsistencies -> Variability
• [x] their performance -> the product
• [x] #20
• [x] I think there is a bit of a confusion of scopes for this paper. I would strictly maintain the line of quality control (i.e. check for product consistency) and counterfeiting. I am sure coatings are important for the reasons mentioned, but those will have been checked in development phase.
• [x] #19
• [x] #21
• [x] #22
• [x] information on unexpected changes in active or excipient source or quality, a active > API
• [x] can be found here > change to mention the authors
• [x] the most appropriate depending on the application -> to suit different applications
• [x] more representative sampling + of the chemical composition of the sample
• [x] Although Raman scattering intensity is linear with concentration within the same confocal plane, transmission Raman signal intensity is slightly biased towards the bulk of the tablet relative to the exterior due to internal scattering [32]. In contrast, DESI MS sampling is biased towards the surface/coating composition. Therefore, in combination, these two techniques should provide a powerful toolkit with which to assess compositional di�erences between pharmaceutical tablet formulations.
  Consider moving this in the first paragraph of the objectives

• [x] Therefore, in combination, these two techniques should provide a powerful toolkit remove should

  Experimental

• [x] Samples were selected from commercially available of-the-shelf products of > off
• [x] Consistent instrument manufacturer info
• [x] Spaces between value and % throughout... same for degree C
• [x] clarify pseudo-random order
• [x] N most intense peaks... how many

• [x] DESI MSI in classification section to DESI M

  Results

• [x] Potentially stack figure 1 to make bigger
• [x] Check sub figure numbering in figure 2 caption
• [x] vs. the predicted class (Figure 2C) shows the shows that all duplicate shows
• [x] Arxiv reference in Variable importance

• [x] cm-1 to superscript in TRS results section

  Conclusions

• [x] Abbreviate API
• [x] #23

  Acknowledgements

• [x] This work was funded by the UK Department of Business, Energy and Industrial Strategy through the projects NMS/IMM19 and NMS/IMM20 of the UK National Measurement System.

  Supplementary

• [x] Fix Fig S4 caption letters