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adamsardar / metaDEGth

metaDEGth: meta-analysis of Differentially Expressed Genes using parametric, empirically-derived P-value distributions
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Incorporate validation data: GSE37699 #15

Closed adamsardar closed 4 years ago

adamsardar commented 5 years ago

GSE37699 studies aquired resistance in cancer cell lines treated with WZ4002. The authors posit that the MEK pathway is heavily involved and show that a MEK inhibitor prevents resistance. A really nice study with a clean pathway to pick out.

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE37699

adamsardar commented 5 years ago

More EGFR inhibitor datasets:

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38310 TKI small molecules and EGFR pathways

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE38302 FGFR pathway upregulation as a result of acquired resistance