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adamsardar / metaDEGth

metaDEGth: meta-analysis of Differentially Expressed Genes using parametric, empirically-derived P-value distributions
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Use optimx rather than optim() for the model fit #18

Open adamsardar opened 4 years ago

adamsardar commented 4 years ago

https://cran.r-project.org/web/packages/optimx/vignettes/Extend-optimx.pdf

Looks like we might unlock improvements.

adamsardar commented 4 years ago

https://stats.stackexchange.com/questions/340555/advantages-disadvantages-of-bfgs-vs-l-bfgs-b-vs-port

adamsardar commented 3 years ago

I see many packages employing L-BFGS via RcppNumerical.

https://cran.rstudio.com/web/packages/RcppNumerical/vignettes/introduction.html

adamsardar commented 3 years ago

Could also use stan (large dependency though)

https://cran.r-project.org/web/packages/StanHeaders/vignettes/stanmath.html