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adamsardar / metaDEGth

metaDEGth: meta-analysis of Differentially Expressed Genes using parametric, empirically-derived P-value distributions
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Look for improvements to the Welch-Satterthwaite Approximation #20

Closed adamsardar closed 4 years ago

adamsardar commented 4 years ago

'An improved procedure for combining Type A and Type B components of measurement uncertainty' looks promising.

adamsardar commented 4 years ago

Looks like the sump of exponentials is a hypoexponential distribution:

https://en.wikipedia.org/wiki/Hypoexponential_distribution

adamsardar commented 4 years ago

Finally! We are dealing with a hyperexponential distribution.

https://www.boost.org/doc/libs/1_60_0/libs/math/doc/html/math_toolkit/dist_ref/dists/hyperexponential_dist.html

adamsardar commented 4 years ago

Got there in the end - we are dealing with a phase-type distribution

https://en.wikipedia.org/wiki/Phase-type_distribution