KnockTF catalogues 570 manually curated RNA-seq and microarray datasets associated with 308 TFs disrupted by different knockdown/knockout techniques and across multiple tissue/cell types. This is a fantastic validation set for the metaDEGth methodology (can we recover the TF given the regulon?).
We also need a source of regulons - use the ones in kockTF? Or perhaps use regulons from Dorothea?
KnockTF catalogues 570 manually curated RNA-seq and microarray datasets associated with 308 TFs disrupted by different knockdown/knockout techniques and across multiple tissue/cell types. This is a fantastic validation set for the metaDEGth methodology (can we recover the TF given the regulon?).
We also need a source of regulons - use the ones in kockTF? Or perhaps use regulons from Dorothea?
http://www.licpathway.net/KnockTF/index.html
https://pubmed.ncbi.nlm.nih.gov/31598675/