We have a handful of expression datasets for small-molecule peturbagens. We could run metaDEGth and compute enriched pathways, but then what? We don't know which pathway is correct.
The Therapeutic Target Database (http://db.idrblab.net/ttd/) catalogues the pathways thought to be important for a given small molecules MoA. How accurate this is, I do not know. But it is at least a move in the right direction of small molecule inference.
We have a handful of expression datasets for small-molecule peturbagens. We could run metaDEGth and compute enriched pathways, but then what? We don't know which pathway is correct.
The Therapeutic Target Database (http://db.idrblab.net/ttd/) catalogues the pathways thought to be important for a given small molecules MoA. How accurate this is, I do not know. But it is at least a move in the right direction of small molecule inference.