Compare against Wilcoxen/GSEA method

adamsardar / metaDEGth

metaDEGth: meta-analysis of Differentially Expressed Genes using parametric, empirically-derived P-value distributions

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Compare against Wilcoxen/GSEA method #4

Open adamsardar opened 5 years ago

adamsardar commented 5 years ago

A Wilcoxon rank-sum test is near equivilent to the GSEA method for set activity enrichment (see the fantastic paper (Gene set enrichment analysis made simple)https://www.ncbi.nlm.nih.gov/pubmed/20048385])

If our parametric method is so sensitive, it should be able to outperform the Wilcoxen at least

adamsardar commented 4 years ago

https://bioconductor.org/packages/release/bioc/html/fgsea.html

FGSEA seems to be the modern version