search

adamsardar / metaDEGth

metaDEGth: meta-analysis of Differentially Expressed Genes using parametric, empirically-derived P-value distributions
Mozilla Public License 2.0
0 stars 1 forks source link

Add a source of transcription factor regulons #6

Closed adamsardar closed 4 years ago

adamsardar commented 5 years ago

Regulons can be thought of as a set of multiple hypotheses - the action of TF A modulates B,C,D ... Z genes.

Finding a source with a compatible reuse license will be key

adamsardar commented 5 years ago

Gernstein et al have used ENCODE data to produce regulons. A reasonable first step?

Gerstein, Architecture of the human regulatory network derived from ENCODE data [2012]

adamsardar commented 5 years ago

There's also the TRUST database, which is licensed under Creative Commons Share Alike: https://www.grnpedia.org/trrust/

TRUST is a text mining database of TF-Target relationships