I have a question about how to understand the result of SCENIC. The first step of the workflow is to do the co-expression analysis between TF and genes. However, when I return back to see the correlation between the TF and its target gene, I didn't find a good correlation there. In addition, the activity score of regulon is not well matching with the gene expression. So how to understand this result?
Hi, thanks for developing such great software!
I have a question about how to understand the result of SCENIC. The first step of the workflow is to do the co-expression analysis between TF and genes. However, when I return back to see the correlation between the TF and its target gene, I didn't find a good correlation there. In addition, the activity score of regulon is not well matching with the gene expression. So how to understand this result?
I find there is an issue related to my question: https://github.com/aertslab/SCENIC/issues/37
Thanks for any suggestion or response.
Best, Dongxu