Comparing RAS scores between independent runs

aertslab / SCENIC

SCENIC is an R package to infer Gene Regulatory Networks and cell types from single-cell RNA-seq data.

http://scenic.aertslab.org

GNU General Public License v3.0

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Comparing RAS scores between independent runs #202

Closed jakalssj3 closed 2 years ago

jakalssj3 commented 3 years ago

I have divided my cells into two sub-populations for which I have run SCENIC analysis independently. Can I directly compare RAS scores for a given regulon between two different runs (I know these may have different number of genes between the two runs)?

s-aibar commented 2 years ago

The regulon scores are mostly meant to compare the activity of a regulon across the cells... i.e. it should be OK to score both versions of regulons across the two subsets of cells, to see in which cells it is more enriched...