pySCENIC is a lightning-fast python implementation of the SCENIC pipeline (Single-Cell rEgulatory Network Inference and Clustering) which enables biologists to infer transcription factors, gene regulatory networks and cell types from single-cell RNA-seq data.
I used pyscenic ctx in CLI and my output has AUC values (third column) What does this mean exactly? I only have values below 0.4. This means that all regulon has no direct target significantly. Does this make no biological sense to me? And what does NES (4. column) mean?
I used pyscenic ctx in CLI and my output has AUC values (third column) What does this mean exactly? I only have values below 0.4. This means that all regulon has no direct target significantly. Does this make no biological sense to me? And what does NES (4. column) mean?