What's the meaning of the suffix of output eregulon's name like "+/+" or "+/-" ?

aertslab / scenicplus

SCENIC+ is a python package to build gene regulatory networks (GRNs) using combined or separate single-cell gene expression (scRNA-seq) and single-cell chromatin accessibility (scATAC-seq) data.

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What's the meaning of the suffix of output eregulon's name like "+/+" or "+/-" ? #488

Closed XinWang19 closed 1 week ago

XinWang19 commented 1 month ago

Hi, I am trying to understand the output of SCENIC+ pipeline. Then I saw different eregulons of particular TF, like ETS1direct+/- and ETS1direct+/+. What are the meanings?

yojetsharma commented 1 month ago

https://github.com/aertslab/scenicplus/issues/466#issuecomment-2348281105 It’s also present in the API part of the tutorial in detail.