SCENIC+ is a python package to build gene regulatory networks (GRNs) using combined or separate single-cell gene expression (scRNA-seq) and single-cell chromatin accessibility (scATAC-seq) data.
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Question about GSEA in the eGRN compilation part #64
I have some questions about the eGRN compilation part.
Is GSEA calculated for each TF-region-gene module? Which genes are in the ranking list L?
My understanding is that the ranking list is the importance score of all downstream genes corresponding to a transcription factor, and set is the downstream genes in the module corresponding to this TF. I don't know if my understanding is correct.
I am not very clear about the detailed process of this part. I hope you can help me out.
Thanks
I have some questions about the eGRN compilation part. Is GSEA calculated for each TF-region-gene module? Which genes are in the ranking list L? My understanding is that the ranking list is the importance score of all downstream genes corresponding to a transcription factor, and set is the downstream genes in the module corresponding to this TF. I don't know if my understanding is correct. I am not very clear about the detailed process of this part. I hope you can help me out. Thanks