aidenlab / Juicebox

Visualization and analysis software for Hi-C data -
https://aidenlab.org/juicebox
MIT License
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BNEWT #489

Open nchernia opened 7 years ago

nchernia commented 7 years ago

It could be useful to implement the newer version of BNEWT in Juicebox and see if it behaves any better on hard-to-normalize matrices.

Matlab code: Appendix. The symmetric algorithm function [x,res] = bnewt(A,tol,x0,delta,Delta,fl) % BNEWT A balancing algorithm for symmetric matrices % % X = BNEWT(A) attempts to find a vector X such that % diag(X)Adiag(X) is close to doubly stochastic. A must % be symmetric and nonnegative. % % X0: initial guess. TOL: error tolerance. % delta/Delta: how close/far balancing vectors can get % to/from the edge of the positive cone. % We use a relative measure on the size of elements. % FL: intermediate convergence statistics on/off. % RES: residual error, measured by norm(diag(x)Ax - e). % Initialise n = size(A,1); e = ones(n,1); res=[]; if nargin < 6, fl = 0; end if nargin < 5, Delta = 3; end if nargin < 4, delta = 0.1; end if nargin < 3, x0 = e; end if nargin < 2, tol = 1e-6; end % Inner stopping criterion parameters. g=0.9; etamax = 0.1; eta = etamax; stop_tol = tol.5; x = x0; rt = tol^2; v = x.(Ax); rk = 1 - v; rho_km1 = rk’rk; rout = rho_km1; rold = rout; MVP = 0; % We’ll count matrix vector products. i = 0; % Outer iteration count. if fl == 1, fprintf(’it in. it res\n’), end while rout > rt % Outer iteration i = i + 1; k = 0; y = e; innertol = max([eta^2rout,rt]); while rho_km1 > innertol %Inner iteration by CG k = k + 1; if k == 1 Z = rk./v; p=Z; rho_km1 = rk’Z; else beta=rho_km1/rho_km2; p=Z + betap; end % Update search direction efficiently. w = x.(A(x.p)) + v.p; alpha = rho_km1/(p’w); ap = alphap; % Test distance to boundary of cone. ynew = y + ap; if min(ynew) <= delta if delta == 0, break, end ind = find(ap < 0); gamma = min((delta - y(ind))./ap(ind)); y = y + gammaap; break end if max(ynew) >= Delta ind = find(ynew > Delta); gamma = min((Delta-y(ind))./ap(ind)); y = y + gammaap; break end y = ynew; rk = rk - alphaw; rho_km2 = rho_km1; Z = rk./v; rho_km1 = rk’Z; end x = x.y; v = x.(Ax); rk = 1 - v; rho_km1 = rk’rk; rout = rho_km1; MVP = MVP + k + 1; % Update inner iteration stopping criterion. rat = rout/rold; rold = rout; res_norm = sqrt(rout); eta_o = eta; eta = grat; if geta_o^2 > 0.1 eta = max([eta,geta_o^2]); end eta = max([min([eta,etamax]),stop_tol/res_norm]); if fl == 1 fprintf(’%3d %6d %.3e \n’, i,k, r_norm); res=[res; r_norm]; end end fprintf(’Matrix-vector products = %6d\n’, MVP)

sa501428 commented 7 years ago

This would be the computeKRNormVector?

nchernia commented 7 years ago

Yes

On Tue, Apr 18, 2017 at 8:42 PM, Muhammad Saad Shamim < notifications@github.com> wrote:

This would be the computeKRNormVector?

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