I am reaching out to seek your expert advice regarding a specific technical challenge I have encountered. I need to modify chromosome identifiers in a .hic file; specifically, I aim to change the chromosome names from RefSeq format (e.g., NC_052533.1) to a more generalized format (e.g., chr1). While I understand that .hic files are binary and require specific handling for such modifications, I am unsure of the best approach to efficiently and accurately make these changes.
Could you please provide me with guidance or point me towards any resources or documentation that might be available? Any scripts or tools you could recommend for this purpose would be greatly appreciated. I am particularly interested in ensuring that these modifications are correctly implemented without compromising the integrity of the data.
Thank you in advance for your time and assistance. I look forward to your valuable insights.
I am reaching out to seek your expert advice regarding a specific technical challenge I have encountered. I need to modify chromosome identifiers in a .hic file; specifically, I aim to change the chromosome names from RefSeq format (e.g., NC_052533.1) to a more generalized format (e.g., chr1). While I understand that .hic files are binary and require specific handling for such modifications, I am unsure of the best approach to efficiently and accurately make these changes.
Could you please provide me with guidance or point me towards any resources or documentation that might be available? Any scripts or tools you could recommend for this purpose would be greatly appreciated. I am particularly interested in ensuring that these modifications are correctly implemented without compromising the integrity of the data.
Thank you in advance for your time and assistance. I look forward to your valuable insights.