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airr-community / gold-standard-datasets

Reference AIRR-Seq datasets for benchmarking tools
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Full length data sets vs datasets amplified with primers in e.g. FR1 #9

Open matsohlin opened 3 years ago

matsohlin commented 3 years ago

Data sets can be generated with primers entirely outside of the IGHV-IGHD-IGHV-encoded sequence but also by using primers within e.g. FR1, e.g. Biomed2. How will different annotation tools address challenges with shorter reads that will cause increased numbers of ambiguous calls?

matsohlin commented 3 years ago

Study PRJNA324093 that features data sets of both naïve and other B cell populations may offer an opportunity to address this matter.