al2na / methylKit

R package for DNA methylation analysis
https://bioconductor.org/packages/release/bioc/html/methylKit.html
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uniting methylRawDB objects with regional resolution and setting destrand=TRUE deletes the original objects #270

Open alexg9010 opened 1 year ago

alexg9010 commented 1 year ago

https://github.com/al2na/methylKit/blob/4735b6fca820c8bda1f84b03e12d19bada2df1fc/R/methylDBFunctions.R#L747

alexg9010 commented 1 year ago
library(methylKit)
data(methylKit)

mdb <- makeMethylDB(methylRawList.obj)     

# works for "base" -resolution
unite(mdb,destrand=TRUE)
mdb # is fine

# breaks for "region" -resolution
mdbt <- tileMethylCounts(mdb) 
# works
unite(mdbt)    

# deletes tabix files of mdbt
unite(mdbt,destrand=TRUE)    

mdbt # breaks !!