Can I perform differential methylation analyses using quantitative traits instead of binary?

[mariazanti]

Hello.

I am currently using methylkit to compare differential methylation between groups.

Can I perform differential methylation analyses using quantitative traits instead of binary? (linear regression instead of logistic)

Thank you in advance for the help.

[alexg9010]

Hi @mariazanti,

this is not possible with methylKit. For using linear regression models I suggest checking out limma or searching among the methylation-array focused packages within bioconductor, like minfi.

Best, Alex