Closed fratajcz closed 1 year ago
Hello @fratajcz ,
Thanks for your interest. I would suggest to use our related R package:
https://github.com/alberto-valdeolivas/RandomWalkRestartMH https://alberto-valdeolivas.github.io/RandomWalkRestartMH/
There you can easily select which networks to use.
Please let me know if this helps.
Alberto
Hi!
Great job at making RWR-M and -MH accessible, even 4 years after publication I can still run it with only minor installation issues.
One question, I want to benchmark RWR-M against a few other methods that do not make use of Pathway information. In fact, I will use Pathway Enrichment Analysis in the external validation pipeline of my results, so this would give RWR-M an unfair headstart.
How can I run RWR-M without the Pathway information?
I have tried the following parameter file:
The layers restart probability makes sure that we don't start at the pathway layer and the inter-layer jump probability makes sure we don't visit it during the walks. Sadly this also prohibits walking from PPI to COEX.
BTW setting a probability to 1.5 hurts me, but they have to sum up to 3.
But I get the following error:
can you help me out?