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amc-heme / scExploreR

Shiny app for single cell omics data visualization
https://amc-heme.github.io/scExploreR/
MIT License
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Inspect numeric threshold based DGE for data with NA values #255

Open wish1832 opened 4 months ago

wish1832 commented 4 months ago

When performing DGE based on a simple numeric threshold, it is possible to encounter a feature with NA values. In this situation, results may differ if the cells with NA values are included in the differential expression computation, as the results would compare cells in each level of the binary threshold to the other cells and cells with NA values. The process of DGE computation in the app should be inspected to determined if NA values are included or excluded, and this should be adjusted accordingly to ensure accurate results are being returned.

jairav commented 1 month ago

@wish1832 @agillen an object with NAs is required to complete this