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andrewhooker / PopED

Population Experimental Design (PopED) in R
https://andrewhooker.github.io/PopED/
GNU Lesser General Public License v3.0
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Covariates per subject #28

Open rhocertara opened 6 years ago

rhocertara commented 6 years ago

Hello Andrew, I am looking for a best way to include different covariates (e.g. weight, race, etc.). I have seen that one can add such in the "create_design" way but this seems to be good for some specifications per group. I would like to know if one can properly implement, for instance, an specific weight per subject for CL. Thank you very much for your help in advance. Roberto

andrewhooker commented 6 years ago

Hi Roberto,

You can do this. The problem is that you slow down the computation of the FIM for the design, making optimization harder. Please see the attached file.

Best regards, Andy

covariate_distributions_2.pdf