Define a model with lag time

[AlejandraSchiavo]

Hi, Can you help me to define a delayed first order absorption model in PopED? Thank you

Alejandra

[andrewhooker]

Hi Alejandra,

Sure. Were you thinking a lag-time delay or transit-compartments?

Best regards, Andy

Andrew Hooker, Ph.D. Professor of Pharmacometrics Dept. of Pharmacy Uppsala University Box 580, 751 23, Uppsala, Sweden Phone: +46 18 471 4355 https://katalog.uu.se/profile/?id=N4-631  https://katalog.uu.se/profile/?id=N4-631 http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/

On 13 Jun 2023, at 14:51, AlejandraSchiavo @.***> wrote:

Hi, Can you help me to define a delayed first order absorption model in PopED? Thank you

Alejandra

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[AlejandraSchiavo]

Hi Andrew, I need a lag-time delay to desrcibe an oral delayed-release formulation. Thank you,

[AlejandraSchiavo]

Maybe it helps: I am working on a model with differential equations. I suppose that the lag time should be defined in the "ff" function, but I can't find an example that indicates where to define it. Thanks, Alejandra

[SayakaMtmt]

Hi I also would like to know how to define lag-time or Duration of zero-order. Dear @andrewhooker , if you could give any advise, I would be happy!

Thanks, Sayaka

[dconrado-eq]

@andrewhooker, @AlejandraSchiavo, @SayakaMtmt - I have the same question on adding a Tlag to a differential equation (not closed form) model. Could you send an example please?