It's not dependent on particular installation. It will work for example with virtualenv setups and will allow python to be found by searching the PATH variable, thus allowing users, who are not root, to supply the python they'd like to use when running platypus.
Suggest using this shebang in Platypus.py driver file
!/usr/bin/env python
https://github.com/andyrimmer/Platypus/blob/1b7d5b5ada68d0df4f6212d097325bf5e6f18e68/src/python/Platypus.py
It's not dependent on particular installation. It will work for example with virtualenv setups and will allow python to be found by searching the PATH variable, thus allowing users, who are not root, to supply the python they'd like to use when running platypus.