andyrimmer / Platypus

Platypus Variant Caller
GNU General Public License v3.0
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Platypus should down-sample by default #7

Open andyrimmer opened 10 years ago

andyrimmer commented 10 years ago

Coverage can be very variable across certain genomes due to collapsed repeats, and variability in the sequencing. Rather than skipping regions when the coverage is too high, Platypus should automatically down-sample coverage per-sample, to a sensible level.

This is already implemented for the alternative haplotype selection model, so it should be straightforward to implement this.