antigenomics / tcr-pmhc-study

Mining TCR:pMHC structural data
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Iterative approach to loops #11

Closed vadimnazarov closed 7 years ago

vadimnazarov commented 7 years ago

Reinforcement learning: https://www.nervanasys.com/demystifying-deep-reinforcement-learning/ https://github.com/matthiasplappert/keras-rl

meta-optimization ?

mikessh commented 7 years ago

One question to consider here: lth Calpha position is influenced by both l-1,l-2,... and l+1,l+2,.... We need to somehow apply symmetry here. Note that for CDR3 (but not CDR1 and AG) the x[0]==x[L-1] + fixed_value, where L is the length. This is known as Omega loop.