search

antigenomics / tcr-pmhc-study

Mining TCR:pMHC structural data
5 stars 1 forks source link

Parameter selection #15

Closed mikessh closed 7 years ago

mikessh commented 7 years ago

Move from x(l,L), y(l,L), z(l,L) to better coordinates/angles

vadimnazarov commented 7 years ago

From #10 

I prefer to treat MHC peptides separately, selecting peptide/antigen features that influence orientation wrt tcr-mhc axis
It can pay off if we first select representative profiles using unsupervised clustering
I would be really happy if we can outline loop/peptide length as a continuous parameter rather than fitting a model for every length