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auerbachs / BMDExpress-3

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BMR 1 SD #7

Open wangjiawen2013 opened 6 months ago

wangjiawen2013 commented 6 months ago

Hi, It is said that "BMR Factor: Also called the benchmark response or critical effect size in some publications, the number of standard deviations at which the BMD is defined. The BMR is defined relative to the response at control. Since both the response at control and the standard deviation used to calculate the BMR are parameters estimated as part of the curve fit, the BMR may change when the model used to fit the data changes. The recommended default BMR factor is 1 (equivalent to 1 standard deviation), consistent with EPA recommendations for continuous data." from https://bmdexpress-2.readthedocs.io/en/feature-readthedocs/bmd_analysis/ While it seems that the BMR does not equal to the standard deviation of control. Could you explain the relationship between BMR and 1 SD ?

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wangjiawen2013 commented 6 months ago

And here is a plot about BMR from https://omicsforum.ca/t/what-is-the-bmr-factor/192 In this plot, the sd equals to that of BMR 1692c581a26181aef826addb795c53b973403150_2_678x500

auerbachs commented 2 months ago

It is 1SD at control. The standard deviation estimate takes into account the SD across the dose response, not just the control samples.