Not use huge lib, like Nape/Box2D or use external JS version for it.
Not use a lot of getPixels/getPixel32/ getData, and all pixel operations on BitmapData that set/return buffers or pixels. Include floodFill, getColorBoundingRect, because it require stop render and grab pixels from GPU
Not use a long property chain's in scrips, because it degraded compiler.
Use blendmodes from list: normal, add, multiple ... Other not supported now.
Not use a lot of separated sprites, 100 unique sprites is drop perf. Use ImageBitmap.draw to manual caching because cacheAsBitmap not supported now.
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Is there a best guide?