ay-lab / mustache

Multi-scale Detection of Chromatin Loops from Hi-C and Micro-C Maps using Scale-Space Representation
MIT License
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KR issue with mcool format while calling loop #66

Open MaybeBio opened 2 months ago

MaybeBio commented 2 months ago

Hi, I recently worked on cool files between mustache and HiCExplorer. I first converted the matrix file from raw hic-pro format to cool file without Normalizing, Then i use HiCExplorer's hicNormalize and hicCorrectMatrix (--correctionMethod KR),

what i did using hicNormalize is this: image then what i did using hicCorrectMatrix (--correctionMethod KR) is this: image so i now have mcool files normalized using KR amongst multiple samples, the question is: image do i need to set -norm KR or just use the default while loop calling