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bcjaeger / melodem-apoe4-het

Workshop and collaborative manuscript
https://bcjaeger.github.io/melodem-apoe4-het/
Creative Commons Attribution Share Alike 4.0 International
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Lit review / background #7

Open bcjaeger opened 1 week ago

bcjaeger commented 1 week ago

The paper could benefit very much from a paragraph in the discussion or intro that summarizes prior studies. For this issue, one person or a small team could

  1. Collect set of relevant papers assessing heterogeneity in the association of apoe4 with dementia or similar design
  2. Add the bibtex info to the manuscript/refs.bib file
  3. (optional) make a small excel data sheet to store notes about each prior study
  4. Draft a paragraph in the manuscript/manuscript.Rmd file that covers prior evidence
  5. If feasible, write a couple sentences at the end of that paragraph indicating what the current study adds to existing knowledge.
alvinthomas commented 4 days ago

Here is a preprint that reviews >100 papers that use causal random forests. It covers common methods and how results are presented in the manuscripts. https://arxiv.org/abs/2404.13356 2404.13356v1.pdf

alvinthomas commented 4 days ago

Here are two papers from cardiovascular disease.

Inoue K, Seeman TE, Horwich T, Budoff MJ, Watson KE. Heterogeneity in the Association Between the Presence of Coronary Artery Calcium and Cardiovascular Events: A Machine-Learning Approach in the MESA Study. Circulation. 2023 Jan 10;147(2):132-141. doi: 10.1161/CIRCULATIONAHA.122.062626. Epub 2022 Oct 31. PMID: 36314118; PMCID: PMC9812415.

Baum A, Scarpa J, Bruzelius E, Tamler R, Basu S, Faghmous J. Targeting weight loss interventions to reduce cardiovascular complications of type 2 diabetes: a machine learning-based post-hoc analysis of heterogeneous treatment effects in the Look AHEAD trial. Lancet Diabetes Endocrinol. 2017 Oct;5(10):808-815. doi: 10.1016/S2213-8587(17)30176-6. Epub 2017 Jul 12. PMID: 28711469; PMCID: PMC5815373.

bcjaeger commented 1 day ago

🎩 tip to @aldengross for this paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564142/

key findings:

(1) There’s an association between apoe4 and dementia, (2) Alden and colleagues tested for effect modification by sex and race.

This paper is from 2021, so its references should include some other relevant recent work on apoe4 heterogeneity.