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bebop / poly

A Go package for engineering organisms.
https://pkg.go.dev/github.com/bebop/poly
MIT License
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MASH template matching #356

Closed Koeng101 closed 8 months ago

Koeng101 commented 11 months ago

So, the idea is that I have many templates and many reads. Many of those templates are similar (perhaps only a 4bp difference in 5000bp). I want a method that will be able to tell me the most likely template that those reads belong to - assuming that all the different sequencing reads go to the same template, but are just a little bit noisy (1/50 random mutation or so).

This would greatly help my sequencing pipelines, and I imagine would help other sequencing pipelines.

github-actions[bot] commented 8 months ago

This issue has had no activity in the past 2 months. Marking as stale.

TimothyStiles commented 8 months ago

There have been demonstrations of template matching using MASH but I'm not so sure if there's anything about extremely small variance between sequences. I'm open to maybe supporting a general template matching function as a demo to start but don't know if I want to maintain that in a stable release yet @Koeng101.