Does ananke handle replicates from the same time point? From reading calculate_slopes in _cluster.py it looks like it would see replicates as an issue. Would it be possible to add an option for computing the mean of samples for each time point and then proceeding?
As a follow up, is it appropriate to simply take the mean of the counts of each ASV for each time point? Will zero imputation and CLR transformation proceed with non-integer "counts"?
Does ananke handle replicates from the same time point? From reading
calculate_slopes
in_cluster.py
it looks like it would see replicates as an issue. Would it be possible to add an option for computing the mean of samples for each time point and then proceeding?