[x] No audio in Safari by default because Autoplay - Stop Media With Sound is set under page settings. Create a notification and link to safari user guide.
[x] Fullscreen mode doesn't work in Safari or Chrome. But does work on Firefox.
If it cannot be fixed, then detect the OS plus the browser string and disable.
[x] Device pixel ratio causes the canvas to render incorrectly, it is only a quarter of the expected size. (see attachment)
[x] The default browser fonts do not render the more eclectic glyphs.