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bhklab / PharmacoDB

Search across publicly available datasets to find instances where a drug or cell line of interest has been profiled.
http://pharmacodb.pmgenomics.ca/
GNU General Public License v3.0
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Drug Sensitivity Score (DSS) #95

Open rikkibrown opened 5 years ago

rikkibrown commented 5 years ago

I have recently come across the PharmacoDB Database and can appreciate that it is a fantastic resource. I was wondering if you could provide information or put me in touch with someone that can explain the calculation for DSS1 (arb.) that is included as a summary statistic for cell line dose-response data.

It is my understanding for drug sensitivity scores that DSS1 and DSS3 have output values between 0 (insensitive) and 100 (highly sensitive), whereas for DSS2, the value is between 0 (insensitive) and 50 (highly sensitive). This is evident in the article cited Yadav et al. (2014) and using the R “DSS” package. However, the DSS values reported for PharmacoDB appear to be between 0 – 0.5. Is there another step of normalisation that has been used to calculate an arbitrary value (ie DSS1 (arb.))? I have yet to find any information about further normalisation in the article Smirnov et al. (2017) which is associated with the database. Thanks kindly in advance.

rikkibrown commented 5 years ago

Just following up because I can see that no one has been assigned and I am still interested in having my query answered.