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bigbio / pgt-pangenome

Protegenomics analysis based on Pangenome references
BSD 2-Clause "Simplified" License
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Analyze the contents of non-canonical pangenome proteome database, including the peptides per class. #3

Closed husensofteng closed 2 months ago

husensofteng commented 10 months ago

The purpose of this issue is to compare quantity and overlap between the protein biotypes and the sources (GRCh and GCA) in the non-canonical proteogenomics database

ypriverol commented 10 months ago

Also, would be good here to discuss, within the canonical pangenome and non-canonical what is the challenge to detect small AA variants, SAAVs. My point is that if the pangenome we have a lot of SAAVs would be more difficult for proteomics tools to detect specific peptides.