RELREC

[VincentBuchheit]

Hi,

Is it possible to create RELREC from PKNCA?

[billdenney]

Hi Vincent,

PKNCA doesn't directly support RELREC, but a simplified RELREC is possible to generate from its output.

What I mean by "simplified RELREC" is that it is very straight-forward to use the interval definitions to determine which group of points were used to calculate a parameter, and at the next level of complexity, it is also relatively straight-forward to give a direct link from the input data to Cmax and Tmax (by the interval, the Tmax value, and the start of the interval) and half-life (by the interval, start time, and Tlast). Most other parameters use all the data within the interval.

Does that answer your question?

[VincentBuchheit]

Hi Bill,

it does, thanks!

Kind regards

Vincent Buchheit

Clinical Pharmacology Data Scientist Head

Senior Manager

Pharmaceutical Sciences

Roche Pharma Research and Early Development

Roche Innovation Center Basel

F. Hoffmann-La Roche Ltd Grenzacherstrasse 124 4070 Basel

Switzerland

Phone +41 61 68 83 767

Mobile +41 79 87 78 267

The right dose for every patient https://www.youtube.com/watch?v=Xrnb_CZbW8c

The benefits of using modeling and simulation in drug development http://www.youtube.com/watch?v=o2ntCRCgpUM&list=PL4C70CE64C0E14B30&index=7

The benefits of using Pharmacokinetic and Pharmacodynamic modeling http://www.youtube.com/watch?v=jxvJHXVIV4E&list=PL4C70CE64C0E14B30&index=6

The benefits of using Clinical Trial Simulation http://www.youtube.com/watch?v=dW4fek6plP4&list=PL4C70CE64C0E14B30&index=5

Disease modeling to inform clinical trial simulation http://www.youtube.com/watch?v=Hhd2U94QM60&list=UUH_ZBgtt6-8-VA52pao0SSA

Entry Into Humans video https://www.youtube.com/watch?v=LNCEqjN0swU

On Mon, 2 Dec 2019 at 12:39, Bill Denney notifications@github.com wrote:

Hi Vincent,

PKNCA doesn't directly support RELREC, but a simplified RELREC is possible to generate from its output.

What I mean by "simplified RELREC" is that it is very straight-forward to use the interval definitions to determine which group of points were used to calculate a parameter, and at the next level of complexity, it is also relatively straight-forward to give a direct link from the input data to Cmax and Tmax (by the interval, the Tmax value, and the start of the interval) and half-life (by the interval, start time, and Tlast). Most other parameters use all the data within the interval.

Does that answer your question?

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