Thank you for your useful tutorial! I am trying to calculate the AUC of my population but because of multiple dosing (not repetitive) I cannot make it seem to work.
I have a dataset where each patient receives per cycle (2 cycles per ID) an IV bolus and then a continuous infusion of 22 hours or 44 hours. Then some patients receive a second bolus and continuous infusion after about 22 hours. I use time after first dose (TAFD) because of multiple dosing.
My dataset kindoff looks like this:
Hi Bill,
Thank you for your useful tutorial! I am trying to calculate the AUC of my population but because of multiple dosing (not repetitive) I cannot make it seem to work. I have a dataset where each patient receives per cycle (2 cycles per ID) an IV bolus and then a continuous infusion of 22 hours or 44 hours. Then some patients receive a second bolus and continuous infusion after about 22 hours. I use time after first dose (TAFD) because of multiple dosing. My dataset kindoff looks like this:
I am stuck because of this error: Rows that are not unique per group and time (column names: TAFD, ID) found within dosing data.
How can I calculate the PK parameters for this multiple dosing dataset? Thanks a lot in advance!
Best, Pascale